- Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations.
Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations.
Scientific reports (2017-07-13)
Jessica L Cooperstone, Kathleen L Tober, Ken M Riedl, Matthew D Teegarden, Morgan J Cichon, David M Francis, Steven J Schwartz, Tatiana M Oberyszyn
PMID28698610
초록
Prolonged tomato consumption can mitigate ultraviolet (UV) light induced sunburn via unknown mechanisms. Dietary carotenoids distributed to skin are hypothesized to protect skin against UV-induced damage, although other phytochemicals may play a role. We hypothesize that tomato consumption would protect against skin cancer. SKH-1 hairless and immunocompetent mice (n = 180) were fed AIN-93G or AIN-93G + 10% tangerine or red tomato powder for 35 weeks. From weeks 11-20, mice (n = 120) were exposed to 2240 J/m
MATERIALS