- Heterobifunctional Dyes: Highly Fluorescent Linkers Based on Cyanine Dyes.
Heterobifunctional Dyes: Highly Fluorescent Linkers Based on Cyanine Dyes.
ChemistryOpen (2017-06-24)
Virginia Wycisk, Katharina Achazi, Ole Hirsch, Christian Kuehne, Jens Dernedde, Rainer Haag, Kai Licha
PMID28638777
초록
Herein, we present a new synthetic route to cyanine-based heterobifunctional dyes and their application as fluorescent linkers between polymers and biomolecules. The synthesized compounds, designed in the visible spectral range, are equipped with two different reactive groups for highly selective conjugation under physiological conditions. By applying indolenine precursors with functionalized benzenes, we achieved water-soluble asymmetric cyanine dyes bearing maleimido and
MATERIALS
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Sigma-Aldrich
N,N,N′,N′-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate, ≥99.0% (TLC/N)