Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing.

Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing.

Molecules (Basel, Switzerland) (2015-10-02)

Thomas M Kohl, Christian H Hornung, John Tsanaktsidis

초록

Significant process intensification of the amination reactions of aryl halides and esters has been demonstrated using continuous flow processing. Using this technology traditionally difficult amination reactions have been performed safely at elevated temperatures. These reactions were successfully conducted on laboratory scale coil reactor modules with 1 mm internal diameter (ID) and on a preparatory scale tubular reactor with 6 mm ID containing static mixers.

MATERIALS

제품 번호

브랜드

제품 설명

723851

Supelco

Dichloromethane solution, contains 10 % (v/v) methanol

471267

Sigma-Aldrich

Dimethyl sulfoxide, ≥99.6%, ReagentPlus^®

41639

Sigma-Aldrich

Dimethyl sulfoxide, BioUltra, Molecular Biology, ≥99.5% (GC)

108987

Sigma-Aldrich

Methyl 3-mercaptopropionate, 98%

278475

Sigma-Aldrich

2-Propanol, anhydrous, 99.5%

B80429

Sigma-Aldrich

4-Bromopyridine hydrochloride, 99%

D2438

Sigma-Aldrich

Dimethyl sulfoxide, sterile-filtered, BioPerformance Certified, meets EP, USP testing specifications, suitable for hybridoma

74875

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8-Octanoyloxypyrene-1,3,6-trisulfonic acid trisodium salt, suitable for fluorescence, ≥90% (HPCE)

276855

Sigma-Aldrich

Dimethyl sulfoxide, anhydrous, ≥99.9%

270997

Sigma-Aldrich

Dichloromethane, anhydrous, ≥99.8%, contains 40-150 ppm amylene as stabilizer

59304

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2-Propanol, BioUltra, Molecular Biology, ≥99.5% (GC)

D9170

Sigma-Aldrich

Dimethyl sulfoxide, PCR Reagent

I9516

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2-Propanol, BioReagent, ≥99.5%, Molecular Biology

D4540

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Dimethyl sulfoxide, ≥99.5% (GC), suitable for plant cell culture

D8418

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Dimethyl sulfoxide, Molecular Biology

D1435

Sigma-Aldrich

Dimethyl sulfoxide, meets EP testing specifications, meets USP testing specifications

D2650

Sigma-Aldrich

Dimethyl sulfoxide, Hybri-Max^™, sterile-filtered, BioReagent, suitable for hybridoma, ≥99.7%

632546

Supelco

Methanol solution, contains 0.10 % (v/v) formic acid, UHPLC, suitable for mass spectrometry (MS), ≥99.5%

733458

Sigma-Aldrich

2-Propanol, electronic grade, 99.999% trace metals basis

676853

Sigma-Aldrich

Dichloromethane, ACS reagent, ≥99.5%, contains 40-150 ppm amylene as stabilizer

109827

Sigma-Aldrich

2-Propanol, Laboratory Reagent, ≥99.5%

I9030

Sigma-Aldrich

Isopropyl alcohol, meets USP testing specifications

190764

Sigma-Aldrich

2-Propanol, ACS reagent, ≥99.5%

320269

Sigma-Aldrich

Dichloromethane, ACS reagent, ≥99.5%, contains 40-150 ppm amylene as stabilizer

24137

Sigma-Aldrich

2-Propanol, puriss., meets analytical specification of Ph. Eur., BP, USP, ≥99.5% (GC)

33539

Sigma-Aldrich

2-Propanol, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.8% (GC)

59300

Sigma-Aldrich

2-Propanol, puriss. p.a., ACS reagent, ≥99.8% (GC)

32222

Sigma-Aldrich

Dichloromethane, puriss. p.a., ACS reagent, reag. ISO, ≥99.9% (GC)

24233

Sigma-Aldrich

Dichloromethane, puriss., meets analytical specification of Ph. Eur., NF, ≥99% (GC)

472301

Sigma-Aldrich

Dimethyl sulfoxide, ACS reagent, ≥99.9%