In situ nanofabrication of hybrid PEG-dendritic-inorganic nanoparticles and preliminary evaluation of their biocompatibility.

In situ nanofabrication of hybrid PEG-dendritic-inorganic nanoparticles and preliminary evaluation of their biocompatibility.

Nanoscale (2014-12-23)

Ana Sousa-Herves, Christian Sánchez Espinel, Amir Fahmi, África González-Fernández, Eduardo Fernandez-Megia

초록

An in situ template fabrication of inorganic nanoparticles using carboxylated PEG-dendritic block copolymers of the GATG family is described as a function of the dendritic block generation, the metal (Au, CdSe) and metal molar ratio. The biocompatibility of the generated nanoparticles analysed in terms of their aggregation in physiological media, cytotoxicity and uptake by macrophages relates to the PEG density of the surface of the hybrids.

MATERIALS

제품 번호

브랜드

제품 설명

PHR1279

Supelco

Sodium ascorbate, Pharmaceutical Secondary Standard; Certified Reference Material

11140

Sigma-Aldrich

(+)-Sodium L-ascorbate, BioXtra, ≥99.0% (NT)

71631

Sigma-Aldrich

Sodium bicarbonate, tested according to Ph. Eur.

60089

Sigma-Aldrich

Potassium bromide, BioUltra, ≥99.5% (AT)

451010

Sigma-Aldrich

Potassium bromide, anhydrous, powder, 99.95% trace metals basis

449962

Sigma-Aldrich

Potassium bromide, anhydrous, powder, 99.999% trace metals basis

A4034

Sigma-Aldrich

(+)-Sodium L-ascorbate, powder, BioReagent, suitable for cell culture

A7631

Sigma-Aldrich

(+)-Sodium L-ascorbate, crystalline, ≥98%

S6297

Sigma-Aldrich

Sodium bicarbonate, BioXtra, 99.5-100.5%

P0838

Sigma-Aldrich

Potassium bromide, BioXtra, ≥99.0%

1613655

USP

Sodium bicarbonate, United States Pharmacopeia (USP) Reference Standard

Y0000039

Sodium ascorbate, European Pharmacopoeia (EP) Reference Standard

792519

Sigma-Aldrich

Sodium bicarbonate, anhydrous, free-flowing, Redi-Dri^™, ACS reagent, ≥99.7%

221864

Sigma-Aldrich

Potassium bromide, FT-IR grade, ≥99% trace metals basis

S6014

Sigma-Aldrich

Sodium bicarbonate, ACS reagent, ≥99.7%

S5761

Sigma-Aldrich

Sodium bicarbonate, powder, BioReagent, for molecular biology, suitable for cell culture, suitable for insect cell culture

401676

Sigma-Aldrich

Sodium hydrogencarbonate, −40-+140 mesh, ≥95%

13433

Sigma-Aldrich

Sodium bicarbonate, puriss., meets analytical specification of Ph. Eur., BP, USP, FCC, E500, 99.0-100.5%, powder

900506

Sigma-Aldrich

Sodium bicarbonate, anhydrous, free-flowing, Redi-Dri^™, ReagentPlus^®, ≥99.5%

S8875

Sigma-Aldrich

Sodium bicarbonate, ReagentPlus^®, ≥99.5%, powder

P9881

Sigma-Aldrich

Potassium bromide, ReagentPlus^®, ≥99.0%

793604

Sigma-Aldrich

Potassium bromide, anhydrous, free-flowing, Redi-Dri^™, ReagentPlus^®, ≥99%

243418

Sigma-Aldrich

Potassium bromide, ACS reagent, ≥99.0%

746444

Sigma-Aldrich

Potassium bromide, anhydrous, free-flowing, Redi-Dri^™, ACS reagent, ≥99%

P16621

Sigma-Aldrich

Phenylacetic acid, 99%

487031

Sigma-Aldrich

Sodium bicarbonate-¹²C, 99.9 atom % ¹²C

50621

Supelco

tert-Butanol, analytical standard

W287806

Sigma-Aldrich

Phenylacetic acid, ≥99%, FCC, FG

308250

Sigma-Aldrich

tert-Butanol, suitable for HPLC, ≥99.5%

471712

Sigma-Aldrich

tert-Butanol, anhydrous, ≥99.5%