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Merck
  • Rapid and highly selective GC/MS/MS detection of heroin and its metabolites in hair.

Rapid and highly selective GC/MS/MS detection of heroin and its metabolites in hair.

Forensic science international (1993-12-01)
A Polettini, A Groppi, M Montagna
초록

A direct treatment of methanol-washed hair with a silylating solution is proposed to extract heroin, O-6-monoacetylmorphine, morphine, acetylcodeine, and codeine, obtaining the simultaneous derivatization of the hydroxylated metabolites and reducing potential sample contamination. Analysis is performed by capillary gas chromatography-tandem mass spectrometry (GC/MS/MS) using multiple selected reaction monitoring. Owing to the selectivity and sensitivity of the GC/MS/MS analysis, and to the extremely simple treatment of the sample, the method fulfils the requirements of both clinical and forensic diagnosis of heroin use.