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Merck
  • Enhancement of rectal absorption of insulin using salicylates in dogs.

Enhancement of rectal absorption of insulin using salicylates in dogs.

The Journal of pharmacy and pharmacology (1983-03-01)
T Nishihata, J H Rytting, A Kamada, T Higuchi, M Routh, L Caldwell
초록

Sodium salicylate and 5-methoxysalicylate both increased the rectal absorption of insulin in dogs when co-administered with insulin in various formulations. Microenema formulations containing 4% gelatin showed the highest insulin bioavailability of the formulations studied whereas microenemas (without gelatin) and suppository formulations were not as effective in enhancing the rectal absorption of insulin.

MATERIALS
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Sigma-Aldrich
2-Hydroxy-5-methoxybenzoic acid, 98%