콘텐츠로 건너뛰기
Merck
  • Concise synthesis of dimemorfan (DF) starting from 3-hydroxymorphinan (3-HM).

Concise synthesis of dimemorfan (DF) starting from 3-hydroxymorphinan (3-HM).

Chemical & pharmaceutical bulletin (2008-07-02)
Jong Yup Kim, Hyoung-Chun Kim, Jeongmin Kim, Jinhwa Lee
초록

Dimemorfan (DF) has been known to possess neuroprotective properties. While this promising compound deserves further biological evaluation, synthetic methods have not improved since Murakami group unveiled the synthetic efforts in 1972. Herein a succinct synthesis toward DF from commercially available 3-hydroxymorphinan (3-HM) is disclosed. Other morphinan analogs have been effectively prepared by adopting the similar methodology.