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Merck
  • Cell-specific intracellular anticancer drug delivery from mesoporous silica nanoparticles with pH sensitivity.

Cell-specific intracellular anticancer drug delivery from mesoporous silica nanoparticles with pH sensitivity.

Advanced healthcare materials (2012-11-28)
Zhong Luo, Kaiyong Cai, Yan Hu, Beilu Zhang, Dawei Xu
초록

A nanoreservoir for efficient intracellular anticancer drug delivery based on mesoporous silica nanoparticles end-capped with lactobionic acid-grafted bovine serum albumin is fabricated. It demonstrates great potential for both cell-specific endocytosis and intracellular pH-responsive controlled release of drugs. A possible endocytosis pathway/mechanism of the smart controlled drug release system is proposed.

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Sigma-Aldrich
Lactobionic acid, 97% (TLC)
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Sigma-Aldrich
Lactobionic acid, ≥97% (TLC), cell impermeant agent
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Lactobionic acid, European Pharmacopoeia (EP) Reference Standard
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