- Total syntheses of angelicoin A, hericenone J, and hericenol A via migratory prenyl- and geranylation-aromatization sequences.
Total syntheses of angelicoin A, hericenone J, and hericenol A via migratory prenyl- and geranylation-aromatization sequences.
The Journal of organic chemistry (2011-11-24)
Jens Cordes, Frederick Calo, Katie Anderson, Toni Pfaffeneder, Sylvain Laclef, Andrew J P White, Anthony G M Barrett
PMID22106838
초록
A five-step synthesis of the natural product angelicoin A using a late stage highly regioselective palladium(0)-catalyzed decarboxylative prenyl migration and aromatization sequence as the key step is reported. The method was extended with geranyl migration in eight-step total syntheses of hericenone J and hericenol A from geraniol.
MATERIALS