- Stereoselective amination of chiral benzylic ethers using chlorosulfonyl isocyanate: total synthesis of (+)-sertraline.
Stereoselective amination of chiral benzylic ethers using chlorosulfonyl isocyanate: total synthesis of (+)-sertraline.
The Journal of organic chemistry (2011-10-26)
Sang Hwi Lee, In Su Kim, Qing Ri Li, Guang Ri Dong, Lak Shin Jeong, Young Hoon Jung
PMID22022991
초록
The stereoselective amination of various chiral benzylic ethers using chlorosulfonyl isocyanate is developed, and the application of this method to the total synthesis of a potent antidepressant, (+)-sertraline, from readily available 1-naphthol is also described.