- 2-Phenylimidazo[1,2-b]pyridazine derivatives highly active against Haemonchus contortus.
2-Phenylimidazo[1,2-b]pyridazine derivatives highly active against Haemonchus contortus.
Bioorganic & medicinal chemistry letters (2011-06-21)
Abdelselam Ali, Teresa Cablewski, Craig L Francis, Ashit K Ganguly, Roger M Sargent, David G Sawutz, Kevin N Winzenberg
PMID21684739
초록
A series of 2-phenylimidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for their in vitro anthelmintic activity against Haemonchus contortus. The most active compounds had in vitro LD(99) values of 30nM, which is comparable to that of the benchmark commercial nematocide, Ivermectin.
MATERIALS