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Merck
  • Straightforward synthesis of enantiopure (R)- and (S)-trifluoroalaninol.

Straightforward synthesis of enantiopure (R)- and (S)-trifluoroalaninol.

Organic & biomolecular chemistry (2010-09-08)
Julien Pytkowicz, Olivier Stéphany, Sinisa Marinkovic, Sébastien Inagaki, Thierry Brigaud
초록

Two efficient routes are reported for the synthesis of both enantiomers of trifluoroalaninol in enantiopure form. The first pathway involves a Strecker-type reaction performed from a chiral trifluoromethyloxazolidine (Fox). The second route, which is more direct, involves, as a key step, the reduction of chiral oxazolidines or imines derived from ethyl trifluoropyruvate.

MATERIALS
제품 번호
브랜드
제품 설명

Sigma-Aldrich
(S)-(+)-2-Amino-1-propanol, 98%
Sigma-Aldrich
DL-Alaninol, 98%