- A concise total synthesis of amphidinolide T2.
A concise total synthesis of amphidinolide T2.
Chemistry (Weinheim an der Bergstrasse, Germany) (2010-08-31)
Huoming Li, Jinlong Wu, Jialu Luo, Wei-Min Dai
PMID20803588
초록
RCM + AD = T2: In the presence of the C16-methylene group, regioselective ring-closing metathesis (RCM) formed the (12E)-endocyclic double bond, which underwent Os-catalyzed asymmetric dihydroxylation (AD) to give the desired 12,13-diol intermediate required for the total synthesis of amphidinolide T2 in 16 linear steps in 8.0% overall yield.
MATERIALS