Unprecedented Cu(I)-catalyzed microwave-assisted three-component coupling of a ketone, an alkyne, and a primary amine.

Unprecedented Cu(I)-catalyzed microwave-assisted three-component coupling of a ketone, an alkyne, and a primary amine.

Organic letters (2010-05-06)

Olga P Pereshivko, Vsevolod A Peshkov, Erik V Van der Eycken

PMID20441203

초록

An efficient, microwave-assisted Cu(I)-catalyzed one-pot coupling of a ketone, an alkyne, and a primary amine (KA(2) coupling) is described, giving access to secondary propargylamines.

MATERIALS

제품 번호

브랜드

제품 설명

P50900

Sigma-Aldrich

Propargylamine, 98%

P50919

Sigma-Aldrich

Propargylamine hydrochloride, 95%