- Intramolecular anodic olefin coupling reactions and the synthesis of cyclic amines.
Intramolecular anodic olefin coupling reactions and the synthesis of cyclic amines.
Journal of the American Chemical Society (2010-02-06)
Hai-Chao Xu, Kevin D Moeller
PMID20131795
초록
Anodic olefin coupling reactions using a tosylamine trapping group have been studied. The cyclizations are favored by the use of a less-polar radical cation and more basic reaction conditions. The most significant factor for obtaining good yields of cyclic product is the use of the more basic reaction conditions. However, a number of factors including the nature of both the solvent and the electrolyte used can influence the yield of the cyclizations. The cyclizations allow for the rapid synthesis of both substituted proline and pipecolic acid type derivatives.