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  • A new one-pot, four-component synthesis of 1,2-amino alcohols: TiCl3/t-BuOOH-mediated radical hydroxymethylation of imines.

A new one-pot, four-component synthesis of 1,2-amino alcohols: TiCl3/t-BuOOH-mediated radical hydroxymethylation of imines.

Organic letters (2008-10-16)
Angelo Clerici, Alessandra Ghilardi, Nadia Pastori, Carlo Punta, Ombretta Porta
초록

An amine, an aldehyde, and methanol can be readily assembled in one pot under very mild conditions through a free-radical multicomponent reaction by using an aqueous acidic TiCl3/t-BuOOH system to afford 1,2-amino alcohols in fair to excellent yields.

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Sigma-Aldrich
Thallium(I) chloride, 99%
Sigma-Aldrich
Thallium(I) chloride, 99.999% trace metals basis