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Merck
  • Determination of bromide in whole blood and urine from humans using gas chromatography-mass spectrometry.

Determination of bromide in whole blood and urine from humans using gas chromatography-mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (2005-02-03)
Shigetoshi Kage, Keiko Kudo, Hideaki Ikeda, Akira Tsujita, Noriaki Ikeda
초록

We devised a sensitive and simple method for determination of bromide in whole blood and urine from humans using gas chromatography-mass spectrometry. Bromide was alkylated with pentafluorobenzyl p-toluenesulphonate in the mixture of acetone and phosphate buffer (pH 6.8). The derivative obtained was analyzed using gas chromatography-mass spectrometry with the positive-ion EI mode. The lower limit of detection for the compound was 1 mg/l. The calibration curve for bromide was linear over the concentration range from 2 to 100 mg/l. With use of this method, levels of bromide in whole blood and urine were determined in cases of poisoning by inhaled brominated hydrocarbons.

MATERIALS
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Sigma-Aldrich
2,3,4,5,6-Pentafluorobenzoic acid, 99%