- Effect of rotenoids from the seeds of Millettia dura on larvae of Aedes aegypti.
Effect of rotenoids from the seeds of Millettia dura on larvae of Aedes aegypti.
Pest management science (2003-10-17)
Abiy Yenesew, Solomon Derese, Jacob O Midiwo, Matthias Heydenreich, Martin G Peter
PMID14561074
초록
A crude chloroform extract of seeds of Millettia dura Dunn (Leguminosae) showed high activity (LC50 = 3.5 microg ml(-1) at 24 h) against second-instar larvae of the mosquito, Aedes aegypti L (Diptera: Culicidae). The rotenoids, deguelin and tephrosin, isolated from the seeds of this plant also showed potent activities, with LC50 values of 1.6 and 1.4 microg ml(-1) at 24 h, respectively. The related rotenoids millettone and millettosin were inactive at 20 microg ml(-1). Saturation at the B/C ring junction and the presence of methoxy groups at C-2 and/or C-3 in deguelin and tephrosin appear to be important for the observed larvicidal activity.
MATERIALS