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Merck

Cell cycle. License withheld--geminin blocks DNA replication.

Science (New York, N.Y.) (2001-02-24)
Z Lygerou, P Nurse
초록

A cell ensures that its genome is replicated only once during its division cycle through a process called licensing. In an enlightening Perspective, Lygerou and Nurse explain how binding of the Geminin protein to Cdt1 blocks the binding of licensing factors to chromatin, inhibiting the onset of S phase (Wohlschlegel et al.).

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Sigma-Aldrich
Anti-Geminin antibody, Mouse monoclonal, clone GEM-1, purified from hybridoma cell culture