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  • Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel.

Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel.

Journal of the American Chemical Society (2011-08-09)
Jun Wang, Chunlong Ma, Yibing Wu, Robert A Lamb, Lawrence H Pinto, William F DeGrado
초록

We describe the use of organosilanes as inhibitors and structural probes of a membrane protein, the M2 proton channel from influenza A virus. Organosilane amine inhibitors were found to be generally as potent as their carbon analogues in targeting WT A/M2 and more potent against the drug-resistant A/M2-V27A mutant. In addition, intermolecular NOESY spectra with dimethyl-substituted organosilane amine inhibitors clearly located the drug binding site at the N-terminal lumen of the A/M2 channel close to V27.

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Sigma-Aldrich
Hydroxylamine hydrochloride, 99.999% trace metals basis
Sigma-Aldrich
Hydroxylamine hydrochloride, 99.995% trace metals basis