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Merck
  • The undecided serpin. The ins and outs of plasminogen activator inhibitor type 2.

The undecided serpin. The ins and outs of plasminogen activator inhibitor type 2.

The FEBS journal (2005-09-24)
Robert L Medcalf, Stan J Stasinopoulos
초록

Plasminogen activator inhibitor type-2 (PAI-2) is a nonconventional serine protease inhibitor (serpin) with unique and tantalizing properties that is generally considered to be an authentic and physiological inhibitor of urokinase. However, the fact that only a small percentage of PAI-2 is secreted has been a long-standing argument for alternative roles for this serpin. Indeed, PAI-2 has been shown to have a number of intracellular roles: it can alter gene expression, influence the rate of cell proliferation and differentiation, and inhibit apoptosis in a manner independent of urokinase inhibition. Despite these recent advances in defining the intracellular function of PAI-2, it still remains one of the most mysterious and enigmatic members of the serpin superfamily.

MATERIALS
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제품 설명

Sigma-Aldrich
PAI-2 human, recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture