추천 제품
일반 설명
HGF (hepatocyte growth factor) is a multifunctional heterodimeric mitogen, with a relative molecular mass (Mr) of 82,000, consisting of a large α-subunit of Mr 69,000 and a small β -subunit of Mr 34,000. The pre-pro precursor protein is composed of 728 residues. HGF is produced by mesenchymal cells.
The hepatocyte growth factor (HGF) gene is located on human chromosome 7q21.1. It has 18 exons, 17 introns and spans approximately 70 kb. Active HGF is made up of a heavy chain and a light chain, connected covalently with the help of a disulfide bridge.
생화학적/생리학적 작용
HGF (hepatocyte growth factor) functions as a ligand for tyrosine kinase receptor Met. Through interaction with Met receptor, it modulates mitogenesis, motility, and morphogenesis in a cell-specific manner. It is implicated in the growth and scattering of specific cell types, EMT (epithelial mesenchymal transition), formation of lumens and tubules, and angiogenesis. HGF-Met is also involved in neural induction, hepatic regeneration, wound healing, and normal fetal development. In primary culture, HGF acts as a strong mitogen for mature parenchymal hepatocytes, and is thought to be a hepatotrophic factor which induces liver regeneration post-partial hepatectomy and liver injury. In HER2-positive patients with metastatic gastric cancer, the serum level of this protein is linked with the outcome and resistance to trastuzumab therapy.
HGF exhibits mitogenic, motogenic and morphogenic effects in various tissues.
물리적 형태
Lyophilized in solution of 10 mM Tris-HCl, pH 7.4, with 1 M NaCl.
제조 메모
Centrifuge the vial prior to opening.
재구성
Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models.
Cao B, et al.
Proceedings of the National Academy of Sciences of the USA, 98(13) , 7443-7448 (2001)
Serum level of hepatocyte growth factor is a novel marker of predicting the outcome and resistance to the treatment with trastuzumab in HER2-positive patients with metastatic gastric cancer.
Takahashi N, et al.
Oncotarget, 7(4), 925-938 (2016)
Molecular cloning and expression of human hepatocyte growth factor.
Nakamura T, et al.
Nature, 342(6248), 440-443 (1989)
Alexandre G Oliveira et al.
Frontiers in endocrinology, 9, 503-503 (2018-09-15)
In obesity, insulin resistance (IR) and diabetes, there are proteins and hormones that may lead to the discovery of promising biomarkers and treatments for these metabolic disorders. For example, these molecules may impair the insulin signaling pathway or provide protection
MET and PI3K/mTOR as a potential combinatorial therapeutic target in malignant pleural mesothelioma.
Rajani Kanteti et al.
PloS one, 9(9), e105919-e105919 (2014-09-16)
Malignant pleural mesothelioma (MPM) is an aggressive disease with a poor prognosis. Studies have shown that both MET and its key downstream intracellular signaling partners, PI3K and mTOR, are overexpressed in MPM. Here we determined the combinatorial therapeutic efficacy of
문서
Role of growth factors in stem cell differentiation and various growth factors for your research at sigmaaldrich.com
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