SRP0134

EZH2/EED/SUZ12/RbAp48/AEBP2 human

recombinant, expressed in baculovirus infected insect cells

• 동의어(들): ENX-1, EZH2, Enhancer of zeste homolog 2, KMT6A, Lysine N-methyltransferase 6A
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in baculovirus infected insect cells
• 분석: ≥80% (SDS-PAGE)
• 형태: aqueous solution
• 분자량: 48 kDa (RbAp48); 51 kDa (EED); 53 kDa (AEBP2); 86 kDa (EZH2); 87 kDa (SUZ12)
• 포장: pkg of 50 μg
• 농도: >0.02 mg/mL
• NCBI 수납 번호: NM_003797 (EED); NM_004456 (EZH2); NM_005610 (RbAP48); NM_015355 (SUZ12); NM_153207 (AEBP2)
• UniProt 수납 번호: Q15910
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... EZH2(2146)

설명

일반 설명

EZH2, EED, SUZ12, RbAp48 and AEBP2 are components of the polycomb repressive complex 2 (PRC2). The highly conserved complex methylates lysine 27 of histone H3. It also has a role in gene silencing and transcription repression.

애플리케이션

EZH2/EED/SUZ12/RbAp48/AEBP2 human is useful for the study of enzyme kinetics, screening inhibitors and selectivity profiling.

단위 정의

One unit is defined as the amount of enzyme required to methylate 1 pmol of substrate/min at 37°C.

물리적 형태

Formulated in 25 mM Tris-HCl, pH 8.0, 138 mM NaCl, 0.05% Tween-20 and 10% glycerol.

제조 메모

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable