SML3872
AZ0108
≥98% (HPLC)
동의어(들):
(S)-4-((3-(3-(1,1-difluoroethyl)-6-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)phenyl)difluoromethyl)phthalazin-1(2H)-one, 4-[[3-[[(6S)-3-(1,1-Difluoroethyl)-5,6-dihydro-6-methyl-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl]phenyl]difluoromethyl]-1(2H)-phthalazinone, AZ 0108
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모든 사진(1)
About This Item
추천 제품
Quality Level
분석
≥98% (HPLC)
형태
powder
색상
white to beige
solubility
DMSO: 2 mg/mL, clear
저장 온도
-10 to -25°C
SMILES string
FC(C1=CC=CC(C(N2[C@@H](C)CN3C(C2)=NN=C3C(F)(F)C)=O)=C1)(F)C(C4=CC=CC=C45)=NNC5=O
생화학적/생리학적 작용
Inhibitor of Poly (ADP-ribose) polymerase PARP1, 2, and 6.
AZ0108 is an inhibitor of Poly (ADP-ribose) polymerase PARP1, 2, and 6 with approximately 100-fold selectivity against PARP3 and TNKS1. It was shown to block centrosome clustering in HeLa cells with an EC50 value of 53 nM and kill a DLBCL lymphoma cancer cell line with a GI50 value of 17 nM. AZ0108 induces replication stress in tumorigenic cells.
AZ0108 is an inhibitor of Poly (ADP-ribose) polymerase PARP1, 2, and 6 with approximately 100-fold selectivity against PARP3 and TNKS1. It was shown to block centrosome clustering in HeLa cells with an EC50 value of 53 nM and kill a DLBCL lymphoma cancer cell line with a GI50 value of 17 nM. AZ0108 induces replication stress in tumorigenic cells.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering
Bioorganic & Medicinal Chemistry Letters, 25(24), 5743-5747 (2015)
Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer
Cancer research, 78(23), 6691-6702 (2018)
Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors
Cell Chemical Biology, 29(12) (2022)
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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