SML0761

Gossypin

≥90% (HPLC)

• 동의어(들): 2-(3,4-Dihydroxyphenyl)-8-(β-D-glucopyranosyloxy)-3,5,7-trihydroxy- 4H-1-benzopyran-4-one, 3,3′,4′,5,7,8-Hexahydroxyflavone 8-glucoside, Gossypetin 8-glucoside
• 실험식(Hill 표기법): C₂₁H₂₀O₁₃
• CAS Number: 652-78-8
• Molecular Weight: 480.38
• MDL number: MFCD00017429
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825593
• NACRES: NA.77

속성

• 생물학적 소스: Hibiscus vitifolius
• 분석: ≥90% (HPLC)
• 형태: powder
• 저장 조건: desiccated
• 색상: , light yellow to dark green-yellow
• solubility: DMSO: 15 mg/mL, clear
• 저장 온도: −20°C
• SMILES string: OC[C@H]1O[C@@H](Oc2c(O)cc(O)c3C(=O)C(O)=C(Oc23)c4ccc(O)c(O)c4)[C@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C21H20O13/c22-5-11-13(27)15(29)17(31)21(32-11)34-19-10(26)4-9(25)12-14(28)16(30)18(33-20(12)19)6-1-2-7(23)8(24)3-6/h1-4,11,13,15,17,21-27,29-31H,5H2/t11-,13-,15+,17-,21+/m1/s1
• InChI key: SJRXVLUZMMDCNG-KKPQBLLMSA-N

설명

일반 설명

Gossypin has anti-inflammatory properties. It inhibits galactose-induced cataract formation and reduces β-amyloid-induced toxicity. Gossypin provides protection against carbon tetrachloride-induced toxicity and bis(2-choloroethyl) sulfide-induced dermal toxicity. It also induces apoptosis in myeloma cells. Gossypin has an anticonvulsant property.

생화학적/생리학적 작용

Gossypin is an anti-inflammatory pentahydroxyflavone glucoside isolated from Hibiscus vitifolius that is used as an herbal remedy for diabetes, jaundice, and inflammation. Gossypin potently inhibits human cancer cell proliferation, including melanoma and glioma cells. Gossypin directly binds and inhibits BRAFV600E and CDK4 kinases, and also regulates Chk1 and Cdc25C in U251 glioma cells.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable