추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen 30 kDa
종 반응성
human, mouse
농도
~1 mg/mL
기술
ELISA: 1:40000
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... OVOL1(5017)
일반 설명
Anti-OVOL1 antibody detects endogenous levels of total OVOL1 protein.
The OVOL1 (ovo like transcriptional repressor 1) gene is mapped to human chromosome 11q13.1. It is widely conserved. In mammals, the gene encodes for C2H2 zinc finger transcription factor. It is predominantly expressed in the human placenta and in the inner root sheath of the hair follicle, suprabasal layer of the epidermis, the ductal portion of the eccrine glands and mature sebocytes of the skin.{36] The protein is localized to cytoplasm.
면역원
The antiserum was produced against synthesized peptide derived from human OVOL1.
Immunogen Range: 1-50
Immunogen Range: 1-50
생화학적/생리학적 작용
The protein encoded by the OVOL1 (ovo like transcriptional repressor 1) gene regulates proliferation and differentiation of epithelial cells. This protein is homologous to that in Drosophila species, which regulates trophoblast differentiation. OVOL1 is known to take part in epidermal keratinisation by inducing differentiation. OVOL1 is associated with atopic dermatitis. OVOL1 is associated with skin morphogenesis and tumorigenesis.
특징 및 장점
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물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
OVO-like 1 regulates progenitor cell fate in human trophoblast development.
Renaud SJ
Proceedings of the National Academy of Sciences of the USA, 112(45), E6175-E6184 (2015)
Activation of the OVOL1-OVOL2 Axis in the Hair Bulb and in Pilomatricoma.
Ito T
The American Journal of Pathology, 186(4), 1036-1043 (2016)
High density genotyping study identifies four new susceptibility loci for atopic dermatitis
David Ellinghaus
Nature Genetics, 45(7), 808-812 (2013)
Chikage Mitoma et al.
Fukuoka igaku zasshi = Hukuoka acta medica, 105(8), 166-173 (2014-12-17)
OVOL1 is an important transcription factor for epidermal keratinization, which suppresses proliferation and switches on the differentiation of keratinocytes. A recent genome-wide association study has revealed that OVOL1 is one of the genes associated with susceptibility to atopic dermatitis. Although
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