생물학적 소스
mouse
항체 형태
crude ascites
항체 생산 유형
primary antibodies
클론
7G7B6, monoclonal
형태
buffered aqueous solution
분자량
30819 Da
종 반응성
human
기술
western blot: 1:100-~1:800
동형
IgG2a
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... IL2RA(3559)
일반 설명
The CD25 gene, also referred to as IL2RA (interleukin 2 receptor subunit α), is mapped to human chromosome 10p15. The gene spans a length of 48 kb with eight exons.
생화학적/생리학적 작용
The interleukin 2 receptor subunit α (IL2RA) gene encodes the α-chain of the IL-2 receptor complex. This receptor complex, made up of α, β, and a common γ chain, binds to its ligand, IL-2, which is a crucial growth factor for T- and B-cells. This ligand-receptor complex plays an important role in the regulation of immune responses. Variation in the chromosomal region containing this gene is associated with type 1 diabetes. This region is also linked to autoimmune thyroid disease indicating its role in autoimmunity. IL2RA has been found to confer a risk for multiple sclerosis.
물리적 형태
Supplied in PBS with 0.09% (W/V) sodium azide
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.
Maier L M, et al.
PLoS Genetics, 5(1), e1000322-e1000322 (2009)
IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations.
Weber F, et al.
Genes and Immunity, 9(3), 259-259 (2008)
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.
Lowe C E, et al.
Nature Genetics, 39(9), 1074-1074 (2007)
Toward further mapping of the association between the IL2RA locus and type 1 diabetes.
Qu H Q, et al.
Diabetes, 56(4), 1174-1176 (2007)
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