추천 제품
생물학적 소스
bovine pancreas
형태
liquid
특이 활성도
1500 units/mL
3000 units/mL
농도
20 mg/mL in Tris buffer
기술
DNA purification: suitable
저장 온도
room temp
유전자 정보
bovine ... RNASE1(282340) , RNASE1(280930)
일반 설명
Ribonuclease A (RNase A), a protein composed of three α helices and seven β strands arranged in two "lobes” holds significance as the prototypical domain-swapped protein. It is known for its diverse oligomeric states. The RNase A family derives its name from bovine pancreatic RNase A and is specific to vertebrates. In humans, this family encompasses eight functional members, showcasing its biological relevance.
For sample preparation in GenElute™ kits.
For sample preparation in GenElute™ kits.
애플리케이션
RNase A solution has been used:
- in apoptosis assay of Hep-2 cells
- for the colorimetric quantification of methylated DNA
- for DNA and RNA extraction
- in DNA laddering analysis
- in cell cycle analysis
- as a component in phosphate-buffered saline (PBS) to incubate cells for flow cytometry
생화학적/생리학적 작용
Ribonuclease A or bovine pancreatic ribonuclease A (RNase A) enzyme is an endoribonuclease that displays a specific ability to cleave single-stranded RNA on the 3′ side of pyrimidine residues. This endonuclease with 124 amino acids plays a key role in gene duplication, cellular metabolism, and cancer therapy. Its overexpression is closely associated with several types of cancer. Hence, RNase A has the potential to be a promising new biomarker for the diagnosis of malignant tumors and is also used as a specific target for new drug discovery. RNase A is commonly used for the isolation of plasmid DNA.
제조 메모
For usage requirements, please refer to the kit procedure.
법적 정보
GenElute is a trademark of Sigma-Aldrich Co. LLC
샘플 준비
제품 번호
설명
가격
신호어
Danger
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Resp. Sens. 1
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Nimesulide inhibits proliferation and induces apoptosis of pancreatic cancer cells by enhancing expression of PTEN
Chu M, et al.
Experimental and Therapeutic Medicine, 16(1), 370-376 (2018)
Homogeneous electrochemiluminescence biosensor for the detection of RNase A activity and its inhibitor
Jiancong N, et al.
Analytical Chemistry, 91, 14751-14756 (2019)
Determination of the presence of 5-methylcytosine in Paramecium tetraurelia
Singh A, et al.
PloS one, 13(10), e0206667-e0206667 (2018)
Bovine Pancreatic Ribonuclease A: Oxidative and Conformational Folding Studies
Scheraga HA, et al.
Methods in Enzymology, 341, 189-221 (2001)
Seasonal changes in broodstock spawning performance and egg quality in ballan wrasse (Labrus bergylta)
Grant B, et al.
Aquaculture (Amsterdam, Netherlands), 464(, 505-514 (2016)
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