The epitope recognized by PLA0116 maps to a region between residues 3075 and the C-terminus (residue 3124) of human E1A binding protein p400 using the numbering given in entry AAK97789.1 (GeneID 57634).
p400 belongs to the SWI2/SNF2 family of chromatin remodeling proteins and is a component of the NuA4 histone acetyltransferase complex. In this complex p400 positively regulates transcription by modifying nucleosome structure. P400 has also been found to play a role in the p52-p21 pathway that regulates p21 transcription and senescence as well as the ARF-p53 pathway that couples cell proliferation to apoptosis.
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