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N4786

NPS 2390

Name: NPS 2390
Brand: SIGMA

≥99% (HPLC), solid

동의어(들):

Quinoxaline-2-carboxylic acid adamantan-1-ylamide

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About This Item

실험식(Hill 표기법):

C₁₉H₂₁ON₃

CAS Number:

226878-01-9

Molecular Weight:

307.39

MDL number:

MFCD05865239

UNSPSC 코드:

12352200

PubChem Substance ID:

329818648

설명

Caution-Not Yet Fully Tested-For Research Use Only-Not For Human Use.

분석

≥99% (HPLC)

형태

solid

색상

white

solubility

DMSO: soluble ~5 mg/mL
H₂O: insoluble

저장 온도

2-8°C

SMILES string

O=C(NC12C[C@@H]3C[C@@H](C[C@@H](C3)C1)C2)c4cnc5ccccc5n4

InChI

1S/C19H21N3O/c23-18(17-11-20-15-3-1-2-4-16(15)21-17)22-19-8-12-5-13(9-19)7-14(6-12)10-19/h1-4,11-14H,5-10H2,(H,22,23)/t12-,13+,14-,19-

InChI key

ZKFVOZCCAXQXBU-KRFSREQESA-N

생화학적/생리학적 작용

Type I metabotropic glutamate receptor antagonist

법적 정보

Sold with the permission of NPS Pharmaceuticals, Inc. striclty for in vitro use only.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Structure-activity relationship studies of NPS 2390: A potent and selective group I metabotropic glutamate receptor antagonist.

Van Wagenen, B.C., et al.

Abstr. Soc. Neurosci, #618.3 (2000)

Functional expression of the extracellular calcium sensing receptor (CaSR) in equine umbilical cord matrix size-sieved stem cells.

Nicola Antonio Martino et al.

PloS one, 6(3), e17714-e17714 (2011-03-26)

The present study investigates the effects of high external calcium concentration ([Ca(2+)](o)) and the calcimimetic NPS R-467, a known calcium-sensing receptor (CaSR) agonist, on growth/proliferation of two equine size-sieved umbilical cord matrix mesenchymal stem cell (eUCM-MSC) lines. The involvement of

Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors.

Charalambos Kaittanis et al.

The Journal of experimental medicine, 215(1), 159-175 (2017-11-17)

Prostate-specific membrane antigen (PSMA) or folate hydrolase 1 (FOLH1) is highly expressed on prostate cancer. Its expression correlates inversely with survival and increases with tumor grade. However, the biological role of PSMA has not been explored, and its role in

Calcium-sensing receptor-mediated osteogenic and early-stage neurogenic differentiation in umbilical cord matrix mesenchymal stem cells from a large animal model.