K3269

Anti-Kindlin-2 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• 동의어(들): Anti-FERMT2, Anti-Fermitin family homolog 2, Anti-KIND2, Anti-MIG2, Anti-Mitogen inducible gene 2 protein, Anti-PLEKHC1, Anti-Pleckstrin homology domain containing, family C member 1, Anti-UNC112, Anti-UNC112B
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: antigen ~72 kDa
• 종 반응성: mouse, rat, canine, human
• 농도: ~1.0 mg/mL
• 기술: indirect immunofluorescence: 2-5 μg/mL using canine MDCK cells; western blot: 1-2 μg/mL using whole extracts of human HeLa, mouse P19 or rat AT3B-1 cells
• UniProt 수납 번호: Q96AC1
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... FERMT2(10979) ; mouse ... Fermt2(218952) ; rat ... Fermt2(289992)

설명

일반 설명

Anti-kindlin-2 recognizes human, mouse, rat and canine kindlin-2. Kindlin-2, also known as fermitin family member 2 (FERMT2) or pleckstrin homology domain-containing family C member 1 (PLEKHC1), is encoded by the gene mapped to human chromosome 14q22.1. Kindlin-2 is a member of the kindlin protein family and has a ubiquitous expression pattern.

애플리케이션

Anti-kindlin-2 antibody produced in rabbit has been used in western blotting.

생화학적/생리학적 작용

Kindlin-2 acts as a focal adhesion protein and controls breast cancer progression by promoting genome instability. Kindlin-2, as an integrin-interacting protein, plays a vital role in integrin activation and integrin-mediated cell-extracellular matrix (ECM) interaction. Kindlin-2 expression is associated with poor prognosis of patients with hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinomas (PDACs). Therefore, kindlin-2 can be considered as a potential biomarker for patients with HCC and PDACs.

물리적 형태

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

저장 및 안정성

For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

기타 정보

In order to obtain best results in different techniques and preparations we recommend determining optimal working concentration by titration test.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable