E4876

17α-Ethynylestradiol

≥98%

• 동의어(들): 17α-Ethynyl-1,3,5(10)-estratriene-3,17β-diol, 19-Nor-1,3,5(10),17α-pregnatrien-20-yne-3,17-diol, Ethinylestradiol
• 실험식(Hill 표기법): C₂₀H₂₄O₂
• CAS Number: 57-63-6
• Molecular Weight: 296.40
• Beilstein: 2419975
• EC Number: 200-342-2
• MDL number: MFCD00003690
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24894585
• NACRES: NA.77

속성

• 생물학적 소스: synthetic
• 무균: non-sterile
• 분석: ≥98%
• 형태: powder
• mp: 182-183 °C (lit.)
• solubility: ethanol: 50 mg/mL, clear, colorless to faintly yellow
• 배송 상태: ambient
• 저장 온도: room temp
• SMILES string: [H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]3(O)C#C)[C@]1([H])CCc4cc(O)ccc24
• InChI: 1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1
• InChI key: BFPYWIDHMRZLRN-SLHNCBLASA-N
• 유전자 정보: human ... ESR1(2099) ; rat ... Afp(24177) , Esr1(24890) , Shbg(24775)

설명

일반 설명

17α-Ethynylestradiol (EE2) is a synthetic hormone. It is a derivative of estradiol (E2). It is implicated in estrogen replacement therapy and suspension of breastfeeding. EE2 is used to treat osteoporosis, menopausal and postmenopausal syndrome. It is also used to treat prostatic cancer and breast cancer in postmenopausal women. EE2 functions as an endocrine-disrupting chemical (EDC).

애플리케이션

17α-Ethynylestradiol has been used to study the effect of exogenous estrogen and selective estrogen receptor modulator (SERM) in rats. It also has been used to increase the concentration of low density lipoprotein (LDL) receptor in rabbit liver.

생화학적/생리학적 작용

17α-Ethynylestradiol is an orally bio-active synthetic estrogen used as an oral contraceptive.

안전성 정보

• 픽토그램: GHS08,GHS07,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H302,H351,H360Fd,H410
• 예방조치 성명서: P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 1 - Carc. 2 - Repr. 1A
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 개인 보호 장비: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges