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Merck
모든 사진(1)

주요 문서

B8429

Sigma-Aldrich

Anti-Bax antibody, Mouse monoclonal

clone 6A7, purified from hybridoma cell culture

동의어(들):

Anti-BCL2L4

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About This Item

MDL number:
UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

mouse

결합

unconjugated

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

6A7, monoclonal

양식

buffered aqueous solution

분자량

antigen 21 kDa (and possibly a dimer of 42 kDa)

종 반응성

mouse, rat, human

농도

2 mg/mL

기술

immunoprecipitation (IP): suitable
microarray: suitable
western blot: 10-60 μg/mL using extract of human breast adenocarcinoma MCF-7 cells, activated with dexamethasone

동형

IgG1

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... BAX(581)
mouse ... Bax(12028)
rat ... Bax(24887)

유사한 제품을 찾으십니까? 방문 제품 비교 안내

일반 설명

Bax is a 21kD integral organelle membrane protein that belongs to the Bcl-2 family and is expressed mainly in the mitochondria. The formation of bax homodimer accelerates apoptotic death whereas its heterodimerization with Bcl-2 or Bcl-xL can block apoptosis. Monoclonal anti-Bax antibody can be used to study the intracellular redistribution of Bax protein upon induction of apoptosis and its unique subcellular localization. This product can also be used in immunoblot analysis to estimate variations in the expression of specific proteins involved in apoptosis signalling. Mouse anti-Bax antibody reacts specifically with the epitope present within the amino acids 12-24 shared by bax from rat, mouse and human.
The B-cell lymphoma 2 (BCL2) associated X, apoptosis regulator (BAX) is mapped to human chromosome 19q13.33.

면역원

synthetic peptide corresponding to amino acids 12-24 of the human Bax sequence, conjugated to KLH.

애플리케이션

Anti-Bax antibody, Mouse monoclonal has been used in the western blotting detection in human retinal pigment epithelium cell lines, glioma, and breast cancer cell lines.
Monoclonal anti-Bax antibody can be used in immunocytochemistry (diluted 1: 1500) and western blot. It is also useful in microarray and immunoprecipitation.

생화학적/생리학적 작용

Mutations in the B-cell lymphoma 2 (BCL2) associated X, apoptosis regulator (BAX) gene is implicated in colorectal cancer. BAX is associated with ovarian follicular dysfunction.

물리적 형태

Solution in phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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시험 성적서(COA)

Lot/Batch Number

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이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Genetics of primary ovarian insufficiency: a review.
Fortuno C and Labarta E
Journal of Assisted Reproduction and Genetics, 31(12), 1573-1585 (2014)
Sunny R Slone et al.
PloS one, 6(7), e21720-e21720 (2011-07-30)
Disruption of 14-3-3 function by alpha-synuclein has been implicated in Parkinson's disease. As 14-3-3s are important regulators of cell death pathways, disruption of 14-3-3s could result in the release of pro-apoptotic factors, such as Bax. We have previously shown that
Primary ovarian insufficiency.
De Vos M, et al.
Lancet, 376(9744), 911-921 (2010)
High-glucose Induces Retinal Pigment Epithelium Mitochondrial Pathways of Apoptosis and Inhibits Mitophagy by Regulating ROS/PINK1/Parkin Signal Pathway.
Yang Y, et al.
bioRxiv, 420653-420653 (2018)
Antitumor effects of arsenic disulfide on the viability, migratory ability, apoptosis and autophagy of breast cancer cells.
Zhao Y, et al.
Oncology Reports, 41(1), 27-42 (2019)

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