B3811

B-9430 trifluoroacetate salt

≥98% (HPLC)

• 동의어(들): D-Arg-Arg-Pro-Hyp-Gly-Igl-Ser-D-Igl-Oic-Arg trifluoroacetate salt, D-Arg-[Hyp³, Igl⁵, D-Igl⁷, Oic⁸]-Bradykinin trifluoroacetate salt
• 실험식(Hill 표기법): C₆₄H₉₅N₁₉O₁₃ · xC₂HF₃O₂
• CAS Number: 180981-09-3
• Molecular Weight: 1338.56 (free base basis)
• UNSPSC 코드: 12352200

속성

• 분석: ≥98% (HPLC)
• 형태: solid
• 저장 조건: protect from light; under inert gas
• solubility: H₂O: ≥2 mg/mL
• 배송 상태: wet ice
• 저장 온도: −20°C

설명

Amino Acid Sequence

Arg-Arg-Pro-Hyp-Gly-Igl-Ser-Igl-Oic-Arg

생화학적/생리학적 작용

B-9430 was developed by Gera at the Stewart laboratory¹ and is a stable, potent, and long lasting Bradykinin (BK) antagonist, a candidate anti-inflammatory drug. B-9430 shows potency at bradykinin B2 (pA₂ = 8.6) and B1 receptors (pA₂ = 7.3). Bradykinin is an important growth factor for small-cell lung cancer (SCLC) and prostate cancer (PC). BK receptors are expressed on almost all lung cancer cell lines and on many PC cells. B-9430 is very resistant to kinases and thus shows a very long action in vivo. This peptide is unique among bradykinin antagonists in that it is active after oral administration.

주의사항

Product is air and light sensitive. Store in the dark.

안전성 정보

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable