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Merck
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주요 문서

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B2432

Sigma-Aldrich

8-Bromoadenosine-3′,5′-cyclic monophosphorothioate, Rp-isomer

≥98% (HPLC), solid

동의어(들):

Rp-8-Br-cAMPS

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C10H10BrN5O5PSNa
Molecular Weight:
446.15
UNSPSC 코드:
41106305
NACRES:
NA.77

Quality Level

200

분석

≥98% (HPLC)

양식

solid

포장

vial of 5 μmol

solubility

water: soluble

저장 온도

−20°C

생화학적/생리학적 작용

Competitive inhibitor of cyclic AMP-dependent protein kinase A (PKA) type I and II. Membrane-permeable analog of the cAMP inhibitor Rp-cAMPS (Prod. No. A-165).

특징 및 장점

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
SLBR2847V
SLBP7999V
SLBP6811V
SLBN4825V
SLBH8348V

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H-89 dihydrochloride hydrate ≥98% (HPLC), powder

Sigma-Aldrich

B1427

H-89 dihydrochloride hydrate

B T Gjertsen et al.
The Journal of biological chemistry, 270(35), 20599-20607 (1995-09-01)
Novel (Rp)-cAMPS analogs differed widely in ability to antagonize cAMP activation of pure cAMP-dependent protein kinase I and II and to antagonize actions of cAMP on gene expression, shape change, apoptosis, DNA replication, and protein phosphorylation in intact cells. These
Ho Lin et al.
Endocrinology, 150(1), 396-403 (2008-08-30)
The roles of cyclin-dependent kinase 5 (Cdk5) in central nervous system and neurodegenerative diseases have been intensely investigated in recent decades. Because protein expressions of Cdk5 and its regulator, p35, have been identified in Leydig cells, it is informative to
Angeline Eymery et al.
Development (Cambridge, England), 143(15), 2767-2779 (2016-06-19)
Oocytes develop the competence for meiosis and early embryogenesis during their growth. Setdb1 is a histone H3 lysine 9 (H3K9) methyltransferase required for post-implantation development and has been implicated in the transcriptional silencing of genes and endogenous retroviral elements (ERVs).
Mei-Chih Chen et al.
American journal of physiology. Cell physiology, 299(2), C516-C527 (2010-05-14)
The signaling mechanisms underlying cell differentiation have been extensively studied with the use of rat PC12 cells as a model system. Nerve growth factor (NGF) is a trophic factor inducing PC12 cell differentiation through the activation of the p35/cyclin-dependent kinase

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