A4486

AMPK (α1/β1/γ3), active, His tagged human

PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• 동의어(들): HAMPKb, MGC17785, MGC33776, MGC57364, PRKAA1, PRKAB1, PRKAG3
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 재조합: expressed in baculovirus infected Sf9 cells
• Quality Level: 200
• 제품 라인: PRECISIO^® Kinase
• 분석: ≥70% (SDS-PAGE)
• 양식: buffered aqueous glycerol solution
• 특이 활성도: 157-213 nmol/min·mg
• 분자량: A1 subunit ~68 kDa; B1 subunit ~38 kDa; G3 subunit ~51 kDa
• UniProt 수납 번호: Q13131; Q9UGI9; Q9Y478
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... PRKAA1(5562) , PRKAB1(5564) , PRKAG3(53632)

설명

생화학적/생리학적 작용

AMPK (A1/B1/G3) is a member of the AMPK family which are heterotrimeric proteins consisting of an α catalytic subunit, and non-catalytic β and γ subunits. AMPKs are an important energy-sensing enzyme group in the cells that monitor energy status particularly in response to stress. AMPKs regulate fatty acid and cholesterol synthesis by regulating the key rate-limiting enzymes acetyl-CoA carboxylase and 3-hydroxy-3-methylglutaryl-CoA reductase. The γ subunit is dominantly expressed in skeletal muscle where it may play a key role in the regulation of energy metabolism.

물리적 형태

Supplied in 50 mM Sodium Phosphate, pH 7.0, with 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, and 25% glycerol.

법적 정보

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H360D
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable