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Merck
모든 사진(1)

문서

485A-1

Sigma-Aldrich

ATRX Rabbit Polyclonal Antibody

동의어(들):

ATP-dependent helicase ATRX, X-linked helicase II, X-linked nuclear protein (XNP)

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모든 사진(1)

About This Item

UNSPSC 코드:
41116161

생물학적 소스

rabbit blood

Quality Level

100
500

결합

unconjugated

항체 형태

IgG fraction of antiserum

항체 생산 유형

primary antibodies

설명

For In Vitro Diagnostic Use in Select Regions

형태

buffered aqueous solution

종 반응성

human

포장

vial of 0.1 mL (concentrate (485A-14))
vial of 0.1 mL (concentrate (485A-14-RUO) Research Use Only)
vial of 0.5 mL (concentrate (485A-15))
vial of 1.0 mL (concentrate (485A-16))
vial of 1.0 mL (concentrate (485A-16-RUO) Research Use Only)
vial of 1.0 mL (concentrate (485A-17-RUO) Research Use Only)
vial of 1.0 mL (pre-dilute ready-to-use (485A-17))
vial of 7.0 mL (concentrate (485A-18-RUO) Research Use Only)
vial of 7.0 mL (pre-dilute ready-to-use (485A-18))

제조업체/상표

Cell Marque™

기술

immunocytochemistry: suitable (formalin-fixed, paraffin-embedded sections 1:50-1:50 (concentrated))

동형

IgG

제어

astrocytoma, brain, glioblastoma, oligodendroglioma

배송 상태

wet ice

저장 온도

2-8°C

시각화

nuclear

일반 설명

Diffuse gliomas are classified based on histological and molecular features to achieve an integrated diagnosis. Molecular diagnostic markers include IDH mutation, 1p/19q co-deletion, and TP53 mutation. ATRX is a chromatin remodeling protein and its mutation status may be used as a molecular diagnostic marker within the diff use glioma classification algorithm. Anti-ATRX is used to identify mutant ATRX by a loss of ATRX expression in neoplastic cells when compared with internal positive controls (endothelial cells, glia, and neurons). Grade II/III astrocytoma classification includes IDH mutant, ATRX mutant, and 1p/19q retention, while grade II/III oligodendroglioma includes IDH mutant, ATRX wildtype, and 1p/19q co-deletion; p53 expression may also serve as an aid in diagnosis. ATRX mutation is frequently, but not always, mutually exclusive with 1p/19q co-deletion.

품질

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

물리적 형태

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

제조 메모

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

기타 정보

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

법적 정보

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

시험 성적서(COA)

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문서 라이브러리 방문

Daniel J Brat et al.
The New England journal of medicine, 372(26), 2481-2498 (2015-06-11)
Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health Organization grades II and III) have highly variable clinical behavior that is not adequately predicted on the basis of histologic class. Some are indolent; others quickly
Akane Yamamichi et al.
Brain tumor pathology, 35(2), 106-113 (2018-03-20)
The IDH-mutant and 1p/19q co-deletion (1p19q codel) provides significant diagnostic and prognostic value in lower-grade gliomas. As ATRX mutation and 1p19q codel are mutually exclusive, ATRX immunohistochemistry (IHC) may substitute for 1p19q codel, but this has not been comprehensively examined.
Matthew D Wood et al.
Diagnostic pathology, 14(1), 29-29 (2019-04-11)
Insights into the molecular underpinnings of primary central nervous system tumors have radically changed the approach to tumor diagnosis and classification. Diagnostic emphasis has shifted from the morphology of a tumor under the microscope to an integrated approach based on
Masako Ikemura et al.
Histopathology, 69(2), 260-267 (2016-01-08)
We performed an immunohistochemical analysis of alpha-thalassaemia/mental retardation syndrome X-linked (ATRX) expression in adult diffuse gliomas, with reference to clinicopathological and genetic features, to determine the utility of this analysis in diagnostic practice. A total of 193 adult diffuse gliomas
David N Louis et al.
Acta neuropathologica, 131(6), 803-820 (2016-05-10)
The 2016 World Health Organization Classification of Tumors of the Central Nervous System is both a conceptual and practical advance over its 2007 predecessor. For the first time, the WHO classification of CNS tumors uses molecular parameters in addition to
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