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Merck
모든 사진(4)

문서

477R-1

Sigma-Aldrich

MAGEC2 (EP405) Rabbit Monoclonal Primary Antibody

동의어(들):

Melanoma-associated antigen C2

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모든 사진(4)

About This Item

UNSPSC 코드:
12352203

생물학적 소스

rabbit

Quality Level

100
500

결합

unconjugated

항체 형태

culture supernatant

항체 생산 유형

primary antibodies

클론

EP405, monoclonal

설명

For In Vitro Diagnostic Use in Select Regions

형태

buffered aqueous solution

종 반응성

human

포장

vial of 0.1 mL concentrate (477R-14)
vial of 0.1 mL concentrate Research Use Only (477R-14-RUO)
vial of 0.5 mL concentrate (477R-15)
vial of 1.0 mL concentrate (477R-16)
vial of 1.0 mL concentrate Research Use Only (477R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (477R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (477R-17)
vial of 7.0 mL pre-dilute ready-to-use (477R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (477R-18-RUO)

제조업체/상표

Cell Marque™

기술

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)

동형

IgG

제어

seminoma

배송 상태

wet ice

저장 온도

2-8°C

시각화

nuclear

일반 설명

Melanoma-associated antigen C2 (MAGEC2), encoded by the testis cancer gene CT10, belongs to a family of proteins that bind E3 RING ubiquitin ligases via a common MAGE homology domain.1-3 The MAGE-RING complexes that are formed enhance the activity of the ubiquitin ligase binding partners. In vitro studies suggest that MAGEC2, which binds to TRIM28, is involved in tumorigenesis through the increased degradation of p53.4 In germ cell tumors, aberrant expression of MAGEC2 is exhibited in seminomas, but is absent in yolk sac tumor and embryonal carcinoma.5-7

품질

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

물리적 형태

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

제조 메모

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기타 정보

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

법적 정보

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Yao-Tseng Chen et al.
Human reproduction (Oxford, England), 26(12), 3232-3243 (2011-10-22)
Cancer/testis (CT) antigens are cancer antigens normally expressed in adult testicular germ cells. The expression of chromosome X-encoded CT antigens (CT-X antigens) in human fetal gonads and in testicular seminomas was examined. The expression of 10 CT-X antigens (MAGEA, NY-ESO-1
Peter K Bode et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 24(6), 829-835 (2011-07-23)
Melanoma-associated gene C2 (MAGEC2) is a recently identified cancer testis antigen expressed in normal testicular and placental tissue. It has been detected in some human carcinomas, but its expression in primary testicular germ cell tumors is unknown. Immunohistochemistry was used
Annikka Weissferdt et al.
Human pathology, 46(3), 376-383 (2015-01-13)
Primary mediastinal seminomas are unusual tumors that can present in a pure form or as part of a mixed germ cell tumor. Contrary to testicular seminomas, little is known about the expression of novel immunohistochemical markers in mediastinal seminomas. This
A O Güre et al.
International journal of cancer, 85(5), 726-732 (2000-03-04)
Assays relying on humoral or T-cell-based recognition of tumor antigens to identify potential targets for immunotherapy have led to the discovery of a significant number of immunogenic gene products, including cancer-testis (CT) antigens predominantly expressed in cancer cells and male
Ran Zhuang et al.
Cancer immunity, 6, 7-7 (2006-04-06)
CT10/MAGE-C2 is a recently identified antigen that, typically of cancer/testis (CT) antigens, can be found in various malignant tumors and in normal adult testis. As with many other CT antigens, our knowledge is based mainly on mRNA expression data. In
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