HCD8MAG15KPX17BK

MILLIPLEX^® Human CD8+ T Cell Magnetic Bead Panel Premixed 17 Plex Space Saver (Bulk) Packaging

Inflammation/Immunology Bead-Based Multiplex Assays using the Luminex technology enables the simultaneous analysis of multiple cytokine and chemokine CD8+ biomarkers in human serum, plasma and cell culture samples.

• 동의어(들): 17-Plex CD8+ T Cell Panel, 17-Plex Magnetic Bead Panel, CD8+ T Cell Magnetic Bead Panel
• UNSPSC 코드: 12161503
• eCl@ss: 32161000
• NACRES: NA.47

속성

• Quality Level: 200
• 종 반응성: human
• 제조업체/상표: Milliplex^®
• assay range: standard curve range: 0.4-1,500 pg/mL; (IL-6); standard curve range: 0.5-2,000 pg/mL; (TNFα); standard curve range: 1-3,500 pg/mL; (MIP-1α); standard curve range: 1-5,000 pg/mL; (Granzyme B); standard curve range: 1-5,000 pg/mL; (IFNγ); standard curve range: 1-5,000 pg/mL; (IL-5); standard curve range: 10-50,000 pg/mL; (Perforin); standard curve range: 10-50,000 pg/mL; (sFasL); standard curve range: 2-10,000 pg/mL; (IL-4); standard curve range: 2-10,000 pg/mL; (sCD137); standard curve range: 2-7,500 pg/mL; (IL-13); standard curve range: 2-7,500 pg/mL; (IL-2); standard curve range: 20-100,000 pg/mL; (Granzyme A); standard curve range: 4-15,000 pg/mL; (GM-CSF); standard curve range: 400-1,650,000 pg/mL; (sFas); standard curve range: 5-20,000 pg/mL; (IL-10); standard curve range: 7-30,000 pg/mL; (MIP-1β)
• 기술: multiplexing: suitable
• 호환성: configured for Premixed
• 검출 방법: fluorometric (Luminex xMAP)
• 배송 상태: wet ice

설명

일반 설명

CD8+ T cells (also known as cytotoxic T cells, cytolytic T cells and killer T cells) belong to a sub-group of T cells capable of inducing the death of infected somatic or tumor cells. T cells that bind weakly to Major Histocompatibility Complex (MHC) self-antigens are positively selected into single-positive CD4+ or CD8+ T cells in the thymus. Those CD8+ T cells that survive and mature after activation become cytotoxic cells, expressing T-cell receptors (TCRs) capable of recognizing specific antigenic peptides bound to Class I MHC molecules and the glycoprotein CD8. Affinity between the CD8 protein and the MHC molecule helps to keep the cytotoxic T cell and target closely bound during antigen specific activation. Once activated, CD8+ T cells are generally classified as having a predefined cytotoxic role within the immune system and undergo IL-2 induced clonal expansion, which increases the number of cells specific for the target antigen. The CD8+ T cells then travel throughout the body in search of antigen-positive somatic/tumor cells.

The Luminex^® xMAP^® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Cytokines/Chemokines

애플리케이션

• Analytes: GM-CSF, sCD137, IFNγ, sFas, sFasL, Granzyme A, Granzyme B, IL-2, IL-4, IL-5, IL-6, IL-10, IL-13, MIP-1α, MIP-1β, TNF-α, Perforin
• Recommended Sample type: serum, plasma or tissue/cell lysate and culture supernatant
• Recommended Sample dilution: Neat
• Assay Run Time: Overnight
• Research Category: Inflammation & Immunology

기타 정보

Sensitivity: Refer to kit protocol for sensitivities of individual biomarkers.

법적 정보

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

안전성 정보

• 픽토그램: GHS08,GHS05,GHS07,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H302 + H312 + H332,H317,H318,H373,H411
• 예방조치 성명서: P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
• 표적 기관: Respiratory Tract
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3