ABT22

Anti-Endophilin-A1 Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): SH3-domain GRB2-like 2, bA335L15.1 (SH3-domain GRB2-like 2), Endophilin A1 BAR domain, SH3 domain protein 2A, Endophilin-1, SH3 domain-containing GRB2-like protein 2
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: mouse, rat
• 기술: western blot: suitable
• 동형: IgG
• NCBI 수납 번호: NP_062408
• UniProt 수납 번호: Q62420
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: mouse ... Sh3Gl2(20404)

설명

일반 설명

A member of the Endophilin family, Endophilin A1 is a protein containing SH3 domains, and has been implicated in the trafficking of clathrin-mediated synaptic vesicle endocytosis within the membrane. It was originally characterized as a presynaptically enriched protein that binds to endocytic proteins polyphosphoinositide synaptojanin and dynamin. Endophilin A1 has been implicated in endocytic vesicle budding when its function in cell-free systems and in living synapses has been disturbed. Along with the SH3 domain, Endophilin A1 contains a BAR domain in the N-terminal region, that has been found to induce and bind membrane curvature. This protein’s expression is localized to the brain, most specifically in the frontal cortex. Markedly high expression is observed in fetal cerebellum.

특이성

Human (94% sequence homology).

The antibody recognizes Endophilin-A1.

면역원

KLH-conjugated linear peptide corresponding to mouse Endophilin-A1.

애플리케이션

This Anti-Endophilin-A1 Antibody is validated for use in WB for the detection of Endophilin-A1.

Western Blot Analysis: 1:500 dilution from a previous lot detected Endophilin-A1 in 10 µg of rat brain and mouse brain membrane tissue lysates.

품질

Evaluated by Western Blot in mouse brain tissue lysate.

Western Blot Analysis: 1:500 dilution of this antibody detected Endophilin-A1 in 10 µg of mouse brain tissue lysate.

표적 설명

~ 42 kDa

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable