추천 제품
생물학적 소스
rabbit
Quality Level
항체 형태
purified antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
liquid
포함
0.1% sodium azide as preservative
종 반응성
human, mouse, rat
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
avoid repeated freeze/thaw cycles
동형
IgG
배송 상태
wet ice
저장 온도
−70°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... UCP2(7351)
일반 설명
Protein A purified rabbit polyclonal antibody. Recognizes the UCP-2 protein.
Recognizes the UCP-2 protein.
면역원
a synthetic peptide [(C)QARAGGGRRYQSTV] corresponding to amino acids 144-157 of human and mouse UCP-2
애플리케이션
ELISA (1:100,000)
Immunoblotting (1:1000)
Immunocytochemistry (1:500)
Immunoblotting (1:1000)
Immunocytochemistry (1:500)
포장
Please refer to vial label for lot-specific concentration.
경고
Toxicity: Standard Handling (A)
기타 정보
Does not react with UCP-1 or UCP-3. Since this antigen sequence is highly conserved, cross-reactivity across a broad range of species is expected. Variables associated with assay conditions will dictate the proper working dilution.
Stuart, J.A., et al. 2001. J. Biol. Chem.276, 18633.
Gimeno, R.E., et al. 1997. Diabetes46, 900.
Gimeno, R.E., et al. 1997. Diabetes46, 900.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Jay D Turner et al.
Circulation research, 106(4), 730-738 (2010-01-09)
Uncoupling protein (UCP)2 is a mitochondrial inner membrane protein that is expressed in mammalian myocardium under normal conditions and upregulated in pathological states such as heart failure. UCP2 is thought to protect cardiomyocytes against oxidative stress by dissipating the mitochondrial
P Brauner et al.
Pediatric research, 49(3), 440-447 (2001-03-03)
Hepatic hematopoiesis is prominent during fetal life and ceases around birth. In rodent liver, the decline of the hepatic hematopoiesis starts abruptly at birth being accompanied by a decrease of mitochondrial uncoupling protein 2 (UCP2) expression in monocytes/macrophages, whereas hepatocytes
Jan Ježek et al.
Antioxidants & redox signaling, 23(12), 958-972 (2015-05-01)
Pancreatic β-cell chronic lipotoxicity evolves from acute free fatty acid (FA)-mediated oxidative stress, unprotected by antioxidant mechanisms. Since mitochondrial uncoupling protein-2 (UCP2) plays antioxidant and insulin-regulating roles in pancreatic β-cells, we tested our hypothesis, that UCP2-mediated uncoupling attenuating mitochondrial superoxide
C Y Zhang et al.
Cell, 105(6), 745-755 (2001-07-07)
beta cells sense glucose through its metabolism and the resulting increase in ATP, which subsequently stimulates insulin secretion. Uncoupling protein-2 (UCP2) mediates mitochondrial proton leak, decreasing ATP production. In the present study, we assessed UCP2's role in regulating insulin secretion.
Yi-Hsieng Samuel Wu et al.
Journal of food and drug analysis, 29(2), 375-388 (2022-06-14)
This study aims to clarify the effects of chicken liver hydrolysates (CLHs) on long-term high-fat diet (HFD)-induced insulin resistance (IR) and hepatosteatosis in mice. In vitro, the 400 μM oleic acid (OA)-added medium successfully stimulated the cellular steatosis on FL83B
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