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Merck
모든 사진(1)

문서

330884

Sigma-Aldrich

(R)-(+)-Atenolol

99%

동의어(들):

(+)-4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide

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About This Item

Linear Formula:
(CH3)2CHNHCH2CH(OH)CH2OC6H4CH2CONH2
CAS Number:
Molecular Weight:
266.34
MDL number:
UNSPSC 코드:
12352112
PubChem Substance ID:
NACRES:
NA.22

분석

99%

광학 활성

[α]25/D +16°, c = 1 in 1 M HCl

mp

148-152 °C (lit.)

SMILES string

CC(C)NC[C@@H](O)COc1ccc(CC(N)=O)cc1

InChI

1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)/t12-/m1/s1

InChI key

METKIMKYRPQLGS-GFCCVEGCSA-N

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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문서 라이브러리 방문

Joni Agustian et al.
Chirality, 29(12), 847-853 (2017-10-01)
Kinetic resolution of (R,S)-atenolol is a faster strategy to produce (S)-atenolol. Since this racemate is a less soluble compound, resolution of its ester offers high concentrations in the process. A good analytical method is required to observe the enantiomer concentrations.
Joni Agustian et al.
Chirality, 29(7), 376-385 (2017-04-26)
As the (R)-enantiomer of racemic atenolol has no β-blocking activity and no lack of side effects, switching from the racemate to the (S)-atenolol is more favorable. Transesterification of racemic atenolol using free enzymes investigated as a resource to resolve the
Kevin F Morris et al.
Chemical physics, 457, 133-146 (2015-08-11)
Molecular dynamics simulations and NMR spectroscopy were used to compare the binding of two β-blocker drugs to the chiral molecular micelle poly-(sodium undecyl-(L)-leucine-valine). The molecular micelle is used as a chiral selector in capillary electrophoresis. This study is part of
Ulisse Garbin et al.
Mediators of inflammation, 2008, 367590-367590 (2008-04-26)
The endothelium plays a key role in the development of atherogenesis and its inflammatory and proliferative status influences the progression of atherosclerosis. The aim of this study is to compare the effects of two beta blockers such as nebivolol and

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