콘텐츠로 건너뛰기
Merck

VAV1

vav 1 guanine nucleotide exchange factor

동의어:
VAV
:
UniProtKB ID:
Clone ID:
  • Human(7409) Summary: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
  • Mouse(22324) vav 1 oncogene
  • Rat(25156) vav 1 guanine nucleotide exchange factor
  • cow(617345) vav 1 guanine nucleotide exchange factor
  • domestic guinea pig(100713221) vav 1 guanine nucleotide exchange factor
  • naked mole-rat(101700388) vav 1 guanine nucleotide exchange factor
  • dog(485016) vav 1 guanine nucleotide exchange factor
  • domestic cat(101097212) vav 1 guanine nucleotide exchange factor
  • sheep(101107354) vav 1 guanine nucleotide exchange factor

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

제품 번호
설명
종별 반응성
응용분야
Monoclonal Anti-VAV1 antibody produced in mouse, clone 9C1, purified immunoglobulin, buffered aqueous solution,
종별 반응성
human
응용분야
ELISA
immunofluorescence

western blot
Anti-VAV1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
종별 반응성
human
응용분야
immunofluorescence
immunohistochemistry
Anti-VAV1 antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse, rat
응용분야
ELISA
western blot
Anti-VAV1 (Ab-174) antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, rat
응용분야
western blot
Anti-phospho-VAV1 (pTyr174) antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse, rat
응용분야
ELISA
western blot

esiRNA

제품 번호
설명
MISSION® esiRNA, targeting mouse Vav1,
mouse
MISSION® esiRNA, targeting human VAV1,
human