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Merck

P4HB

prolyl 4-hydroxylase, beta polypeptide

동의어:
DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB
:
UniProtKB ID:
Clone ID:
  • Human(5034) Summary: This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
  • Mouse(18453) prolyl 4-hydroxylase, beta polypeptide
  • Rat(25506) prolyl 4-hydroxylase, beta polypeptide
  • sheep(100135700) prolyl 4-hydroxylase, beta polypeptide
  • Zebrafish(406673) procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide
  • sheep(101115218) prolyl 4-hydroxylase, beta polypeptide
  • chicken(374091) prolyl 4-hydroxylase, beta polypeptide
  • naked mole-rat(101712215) prolyl 4-hydroxylase, beta polypeptide
  • cow(281373) prolyl 4-hydroxylase, beta polypeptide
  • dog(483369) prolyl 4-hydroxylase, beta polypeptide
  • domestic guinea pig(100733944) prolyl 4-hydroxylase, beta polypeptide
  • Domestic Rabbit(100328595) prolyl 4-hydroxylase, beta polypeptide
  • domestic cat(101099917) prolyl 4-hydroxylase, beta polypeptide

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Antibodies

제품 번호
설명
종별 반응성
응용분야
Anti-P4HB (AB2) antibody produced in rabbit, affinity isolated antibody,
종별 반응성
bovine, dog, horse, human, mouse, pig, rabbit, rat
응용분야
immunohistochemistry
western blot
Anti-PDI Antibody, clone 1M19 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
종별 반응성
bovine, canine, feline, human, monkey, mouse, porcine, rat
응용분야
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-P4HB antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
종별 반응성
human, mouse, rat
응용분야
immunofluorescence
immunohistochemistry

western blot
Anti-P4HB antibody produced in rabbit, ,
종별 반응성
human, mouse, rat
응용분야
immunofluorescence
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-P4HB antibody produced in rabbit, ,
종별 반응성
human
응용분야
immunohistochemistry
western blot

Small Molecule - Inhibitor

제품 번호
설명
Lomitapide, ≥98% (HPLC),
human

esiRNA

제품 번호
설명
MISSION® esiRNA, targeting mouse P4hb,
mouse
MISSION® esiRNA, targeting human P4HB,
human