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Merck

MAPK14

mitogen-activated protein kinase 14

동의어:
CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA
:
UniProtKB ID:
Clone ID:
  • Human(1432) Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
  • Mouse(26416) mitogen-activated protein kinase 14
  • Rat(81649) mitogen activated protein kinase 14
  • naked mole-rat(101715692) mitogen-activated protein kinase 14
  • domestic guinea pig(100723285) mitogen-activated protein kinase 14
  • chicken(421183) mitogen-activated protein kinase 14
  • Horse(100063532) mitogen-activated protein kinase 14
  • dog(403856) mitogen-activated protein kinase 14
  • domestic cat(101101135) mitogen-activated protein kinase 14
  • Domestic Rabbit(100341695) mitogen-activated protein kinase 14
  • sheep(100217411) mitogen-activated protein kinase 14
  • cow(534492) mitogen-activated protein kinase 14

Custom & Knockdown Gene Products

ELISA

제품 번호
설명
Phosphotyrosine MAPK14 / Mitogen-activated Protein Kinase 14 ELISA Kit, ,
human
Phospho-p38 α (pThr180 / pTyr182) and pan-p38 ELISA Kit, for detection of phospho-p38 alpha (pThr180 / pTyr182) and pan-p38 in human or mouse cell and tissue lysates,
human
Cell-Based ELISA Sampler Kit for detecting phospho-ERK1/2 (pThr202/pTyr204), phospho-JNK (pThr183/pTyr185), and phospho-p38 MAPK (pThr180/pTyr182) in cultured cell lines, 192 assays,
rat, human, mouse

Antibodies

제품 번호
설명
종별 반응성
응용분야
Anti-p38/SAPK2 Antibody, clone 2F11, clone 2F11, from mouse,
종별 반응성
human, mouse, rat
응용분야
western blot
Anti-p38 MAPK antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse, rat
응용분야
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-p38 MAPK antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse, rat
응용분야
ELISA
immunohistochemistry
Anti-p38 MAPK antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse, rat
응용분야
ELISA
western blot
Anti-phospho-p38 MAPK (pTyr182) antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse, rat
응용분야
ELISA
immunohistochemistry

western blot

Small Molecule - Inhibitor

제품 번호
설명
VX-745, ≥98% (HPLC),
human
SB 202190, ≥98% (HPLC),
human
PD 169316, ≥98% (HPLC), solid,
human
2-Amino-3-benzyloxypyridine, 99%,
human
Naproxen, meets USP testing specifications,
human, rat

Proteins

제품 번호
설명
p38α/SAPK2a (T106M) Protein, active, 10 µg, Active, N-terminal GST-tagged, recombinant, human, full-length p38α/SAPK2a containing the mutation T106M. Activated using DD-MKK6 & repurified using glutathione-agarose. For use in Kinase Assays.,
human
p38α/SAPK2a (6His-tag) Protein, unactive, 50 µg, ,
human
p38α/SAPK2a Protein, active, 10 µg, Active, N-terminal GST tagged, recombinant, full length p38α/SAPK2a, for use in Kinase Assays.,
human

esiRNA

제품 번호
설명
MISSION® esiRNA, targeting human MAPK14,
human
MISSION® esiRNA, targeting mouse Mapk14,
mouse