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Merck

CDK8

cyclin-dependent kinase 8

동의어:
K35
:
UniProtKB ID:
Clone ID:
  • Human(1024) Summary: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq, Jul 2008]
  • Mouse(264064) cyclin-dependent kinase 8
  • domestic guinea pig(100718250) cyclin-dependent kinase 8
  • naked mole-rat(101719987) cyclin-dependent kinase 8
  • sheep(101115551) cyclin-dependent kinase 8
  • Domestic Rabbit(100353845) cyclin-dependent kinase 8
  • domestic cat(101086278) cyclin-dependent kinase 8
  • Zebrafish(373868) cyclin-dependent kinase 8
  • cow(507149) cyclin-dependent kinase 8
  • dog(486035) cyclin-dependent kinase 8
  • chicken(428080) cyclin-dependent kinase 8
  • Horse(100050819) cyclin-dependent kinase 8
  • fruit fly(39157) Cyclin-dependent kinase 8

Custom & Knockdown Gene Products

  • siRNA

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  • shRNA

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  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

제품 번호
설명
종별 반응성
응용분야
Anti-CDK8 Antibody, clone 7L5X2, Rabbit Monoclonal, ,
종별 반응성
human, rat
응용분야
western blot
ANTI-CDK8 antibody produced in mouse, clone 5H4, purified immunoglobulin, buffered aqueous solution,
종별 반응성
human
응용분야
ELISA
western blot
Anti-CDK8 antibody produced in rabbit, IgG fraction of antiserum,
종별 반응성
bovine, dog, horse, human, mouse, pig, rabbit
응용분야
western blot
Anti-CDK8 antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse
응용분야
ELISA
western blot
Anti-CDK8 antibody produced in rabbit, ,
종별 반응성
human, mouse, rat
응용분야
immunoprecipitation (IP)
western blot

Small Molecule - Inhibitor

제품 번호
설명
Olomoucine, ≥98% (HPLC),
human, rat

esiRNA

제품 번호
설명
MISSION® esiRNA, targeting mouse Cdk8,
mouse
MISSION® esiRNA, targeting human CDK8,
human