UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
Synonyms:
BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT 1-1, UGT1, UGT1A
Species:
Human UGT1A1 (54658), Mouse Ugt1a1 (394436), Rat Ugt1a1 (24861), Zebrafish ugt1a1 (641488), chicken UGT1A1 (424028), domestic cat UGT1A1 (493955), Horse UGT1A1 (100065342), cow UGT1A1 (751790), sheep UGT1A1 (100534644)
UniProtKB ID:
Gene ID:
- Human(54658) Summary: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq, Jul 2008]
- Mouse(394436) UDP glucuronosyltransferase 1 family, polypeptide A1
- Rat(24861) UDP glucuronosyltransferase 1 family, polypeptide A1
- Zebrafish(641488) UDP glucuronosyltransferase 1 family polypeptide a1
- chicken(424028) UDP glucuronosyltransferase 1 family, polypeptide A1
- domestic cat(493955) UDP glucuronosyltransferase 1 family, polypeptide A1
- Horse(100065342) UDP glucuronosyltransferase 1 family, polypeptide A1
- cow(751790) UDP glucuronosyltransferase 1 family, polypeptide A1
- sheep(100534644) UDP glucuronosyltransferase 1 family, polypeptide A1
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