TGFB2
transforming growth factor, beta 2
Synonyms:
LDS4, TGF-beta2
Species:
Human TGFB2 (7042), Mouse Tgfb2 (21808), Rat Tgfb2 (81809), dog TGFB2 (488596), Zebrafish tgfb2 (369194), domestic guinea pig Tgfb2 (100720726), chicken TGFB2 (421352), cow TGFB2 (534069), domestic cat TGFB2 (101093414), sheep TGFB2 (554322) ...More
UniProtKB ID:
Gene ID:
- Human(7042) Summary: This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
- Mouse(21808) transforming growth factor, beta 2
- Rat(81809) transforming growth factor, beta 2
- dog(488596) transforming growth factor, beta 2
- Zebrafish(369194) transforming growth factor, beta 2
- domestic guinea pig(100720726) transforming growth factor, beta 2
- chicken(421352) transforming growth factor, beta 2
- cow(534069) transforming growth factor, beta 2
- domestic cat(101093414) transforming growth factor, beta 2
- sheep(554322) transforming growth factor, beta 2
- Domestic Rabbit(100009371) transforming growth factor, beta 2
- naked mole-rat(101707457) transforming growth factor, beta 2
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-TGF β2, C-Terminal antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
immunohistochemistry
ANTI-TGF BETA 2(C-TERMINAL) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-Transforming Growth Factor-β, pan antibody produced in rabbit, IgG fraction of antiserum, lyophilized powder,
Species Reactivity
amphibian, human, pig
Application
microarray
neutralization
western blot
neutralization
western blot