CR1
complement component (3b/4b) receptor 1 (Knops blood group)
Synonyms:
C3BR, C4BR, CD35, KN
Species:
Human CR1 (1378), dog CR1 (609328), domestic cat CR1 (101094393), Domestic Rabbit CR1 (100144334), naked mole-rat Cr1 (101704987)
UniProtKB ID:
Gene ID:
- Human(1378) Summary: This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]
- dog(609328) complement component (3b/4b) receptor 1 (Knops blood group)
- domestic cat(101094393) complement component (3b/4b) receptor 1 (Knops blood group)
- Domestic Rabbit(100144334) complement component (3b/4b) receptor 1 (Knops blood group)
- naked mole-rat(101704987) complement component (3b/4b) receptor 1 (Knops blood group)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-CD35/CR1 Antibody, clone 2A0Q1, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Monoclonal Anti-CD35-APC antibody produced in mouse, clone E11,
Species Reactivity
Application
flow cytometry
Monoclonal Anti-CD35 antibody produced in mouse, clone E11,
Species Reactivity
human, nonhuman primates
Application
flow cytometry
Anti-CR1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-CR1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
esiRNA
Product Number
Description
Species