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  • [Preparation of chiral alcohol by stereoselective reduction of acetophenone and chloroacetophenone with yeast cells].

[Preparation of chiral alcohol by stereoselective reduction of acetophenone and chloroacetophenone with yeast cells].

Wei sheng wu xue bao = Acta microbiologica Sinica (2005-11-10)
Zhimin Ou, Jianping Wu, Lirong Yang, Peilin Cen
ABSTRACT

Four strains of microorganisms which have activity of chloroacetophenone reduction were screened, in which Saccharomyces cerevisiae B5 showed the highest activity and good stereoselectivity. This strains showed different activity on the reduction of various substrates in the following order: 2'-chloroacetophenone > 2-chloromethylacetophenone > 4'-chloroacetophenone > 3'-chloroacetophenone > acetophenone. Ethanol is the best cosubstrate and its optimal concentration is 5%.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
2-Chloroacetophenone, 98%
Sigma-Aldrich
3′-Chloroacetophenone, 98%
Sigma-Aldrich
2-Chloroacetophenone, purum, ≥98.0% (GC)